Meds for alzheimer - Jun 7, 2021 · Matt York/AP. The Food and Drug Administration approved the drug aducanumab to treat patients with Alzheimer's disease on Monday. It is the first new drug approved by the agency for Alzheimer's ...

 
Jan 7, 2023 · Credit: Juan Gaertner/SPL. The US Food and Drug Administration (FDA) has approved lecanemab, the second-ever treatment for Alzheimer’s disease that is intended to tackle the root of the ... . Hinca p

Huperzine A. Huperzine A (pronounced HOOP-ur-zeen) is a moss extract that has been used in traditional Chinese medicine for centuries. It has properties similar to those of cholinesterase inhibitors, one class of FDA-approved Alzheimer's medications. As a result, it is promoted as a treatment for Alzheimer's disease. Sep 6, 2023 · Overview of using medications to treat anxiety in Alzheimer's patients. Medications for treating anxiety. Anxiety symptoms are fairly common among patients with Alzheimer's Disease (AD). Such symptoms are likely to make patient care more problematic and, therefore, increase the risk of nursing home placement. Aricept (donepezil) as low as. $13. View other Cholinesterase Inhibitors. Donepezil (Aricept) is an inexpensive drug used to treat mild to moderate dementia caused by Alzheimer's disease. It is more popular than comparable drugs. It is available in generic and brand versions. Aug 3, 2022 · Treatments for Alzheimer’s Disease. Learn more about initial patient support strategies, the latest approved drugs to slow the disease’s progress, and the status of new clinical trials. For sleep changes due primarily to Alzheimer’s disease, there are non-drug and drug approaches to treatment. Most experts and the National Institutes of Health (NIH) strongly encourage use of non-drug measures rather than medication. Studies have found that sleep medications generally do not improve overall sleep quality for older adults.Aug 3, 2022 · Treatments for Alzheimer’s Disease. Learn more about initial patient support strategies, the latest approved drugs to slow the disease’s progress, and the status of new clinical trials. People with Alzheimer’s disease may become agitated or aggressive as the disease gets worse. Agitation means that a person is restless or worried. He or she doesn’t seem to be able to settle down. Agitation may cause pacing, sleeplessness, or aggression, which is when a person lashes out verbally or tries to hit or hurt someone.Jan 22, 2021 · Treatment for Alzheimer's disease, the devastating condition that affects more than 5 million Americans, has remained notoriously elusive for decades. Now, a small study released by drug company Eli Lilly offers at least a flicker of hope: It shows that the experimental drug donanemab may significantly slow patients’ cognitive decline. Galantamine (Razadyne): This drug is used to prevent or slow the symptoms of mild to moderate AD. It comes as a tablet, extended-release capsule, or oral solution (liquid). Memantine (Namenda ...For sleep changes due primarily to Alzheimer’s disease, there are non-drug and drug approaches to treatment. Most experts and the National Institutes of Health (NIH) strongly encourage use of non-drug measures rather than medication. Studies have found that sleep medications generally do not improve overall sleep quality for older adults. A neurological exam may include testing: Reflexes. Muscle tone and strength. Ability to get up from a chair and walk across the room. Sense of sight and hearing. Coordination. Balance. Lab tests Blood tests may help rule out other potential causes of memory loss and confusion, such as a thyroid disorder or vitamin levels that are too low.Jun 7, 2021 · Matt York/AP. The Food and Drug Administration approved the drug aducanumab to treat patients with Alzheimer's disease on Monday. It is the first new drug approved by the agency for Alzheimer's ... There are three drugs of this type: donepezil ( Aricept ), galantamine ( Razadyne ), and rivastigmine ( Exelon ). Aricept is the only treatment approved by the FDA for all stages of Alzheimer’s ...There may not be an obvious cause. But many times, there are triggers you can spot before or during a problem. Common ones include: Discomfort from lack of sleep, side effects from medication, or ... Manage medications. Some antidepressant medications, such as bupropion and venlafaxine, can lead to insomnia. Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer's but also can cause insomnia. If the person with dementia is taking these kinds of medications, talk to the doctor.Huperzine A. Huperzine A (pronounced HOOP-ur-zeen) is a moss extract that has been used in traditional Chinese medicine for centuries. It has properties similar to those of cholinesterase inhibitors, one class of FDA-approved Alzheimer's medications. As a result, it is promoted as a treatment for Alzheimer's disease. Antipsychotic medications can treat dementia symptoms such as aggression or psychosis. But these drugs can cause serious side effects. ... Alzheimer’s disease is the most common form of dementia ...Mar 18, 2020 · A better approach to treatment. Recently, researchers at Weill Cornell Institute of Geriatric Psychiatry in New York studied the effectiveness of a new home-delivered therapy called Problem Adaptation Therapy, or PATH, in participants with depression and dementia or mild cognitive impairment. In the PATH intervention, therapists meet with the ... The Food and Drug Administration on Monday approved Biogen 's Alzheimer's disease drug aducanumab, making it the first medication cleared by U.S. regulators to slow cognitive decline in people ...Feb 18, 2022 · However, there is hope for an Alzheimer’s cure breakthrough 2022. Currently, Aducanumab is only approved for use in select patients with mild cognitive impairment or early Alzheimer’s disease. Before the treatment can be administered, all individuals with AD must undergo a PET scan to determine if they have amyloid plaques. Feb 18, 2022 · However, there is hope for an Alzheimer’s cure breakthrough 2022. Currently, Aducanumab is only approved for use in select patients with mild cognitive impairment or early Alzheimer’s disease. Before the treatment can be administered, all individuals with AD must undergo a PET scan to determine if they have amyloid plaques. Aug 30, 2023 · While Alzheimer's drugs don't cure the disease, they can improve quality of life and help prolong independence. There are two types of medications approved to treat Alzheimer's: those that can temporarily ease some symptoms, and those that can slow the progression of the disease. Mar 18, 2020 · A better approach to treatment. Recently, researchers at Weill Cornell Institute of Geriatric Psychiatry in New York studied the effectiveness of a new home-delivered therapy called Problem Adaptation Therapy, or PATH, in participants with depression and dementia or mild cognitive impairment. In the PATH intervention, therapists meet with the ... Aug 30, 2023 · In 2023, the U.S. Food and Drug Administration (FDA) approved lecanemab (Leqembi) for people with mild Alzheimer's disease and mild cognitive impairment due to Alzheimer's disease. A phase 3 clinical trial found that the medicine slowed cognitive decline in people with early Alzheimer's disease. Even though the chief cause of behavioral symptoms is the effect of Alzheimer's disease on the brain, an examination may reveal other treatable conditions that are contributing to the behavior. Contributing conditions may include: Drug side effects. Many people with Alzheimer's take prescription medications for other health issues.Create a calm place for them. Cut out background noise from the TV or radio, clear away clutter, and make their daily tasks as simple as possible. Check for physical reasons they might be agitated ... Aug 30, 2023 · Infections and immune disorders. Dementia-like symptoms can result from a fever or other side effects of the body's attempt to fight off an infection. Multiple sclerosis and other conditions caused by the body's immune system attacking nerve cells also can cause dementia. Metabolic or endocrine problems. Sep 27, 2021 · The cholinesterase inhibitors are the main first-line treatment for Alzheimer’s disease. These drugs attempt to make up for depleted levels of acetylcholine. For moderate to severe disease, doctors often add the NMDA receptor drug. Researchers are still exploring the exact role of the new MAB drug. Aducanumab (Aduhelm) is a MAB and is the ... Family members often want their loved one to continue on dementia meds. Alzheimer’s advocate Meryl Comer, who cared for her husband with early onset AD at home throughout his illness (see Aug 2014 news story), noted that the drugs seemed to help control his symptoms. “Memantine made him more cooperative, and that made the difference between ...EVIDENCE-BASED ANSWER. ATYPICAL ANTIPSYCHOTICS ARE EFFECTIVE; so are selective serotonin reuptake inhibitors (SSRIs), and they may be safer. Atypical antipsychotics are an effective short-term (6-12 weeks) treatment for aggressive behavior in patients with Alzheimer’s disease because they consistently decrease aggression scores (strength of recommendation [SOR]: A, multiple randomized ... The cholinesterase inhibitors are the main first-line treatment for Alzheimer’s disease. These drugs attempt to make up for depleted levels of acetylcholine. For moderate to severe disease, doctors often add the NMDA receptor drug. Researchers are still exploring the exact role of the new MAB drug. Aducanumab (Aduhelm) is a MAB and is the ...Aricept (donepezil) as low as. $13. View other Cholinesterase Inhibitors. Donepezil (Aricept) is an inexpensive drug used to treat mild to moderate dementia caused by Alzheimer's disease. It is more popular than comparable drugs. It is available in generic and brand versions. Evidence Summary. A 2018 meta-analysis examining medications used to alleviate agitation in all types of dementia included 36 RCTs with a total of 5,585 participants (mean age = 81.8 years ± 4.9 ...Possible Side Effects. Donepezil (Aricept ®) Yes. All stages of dementia (not recommended in FTD) Nausea, diarrhea, vomiting, upset stomach, lack of hunger, weight loss or low heart rate. Other less common problems are feeling tired, having trouble sleeping, vivid dreams or muscle cramps. Rivastigmine (Exelon ®) Yes. EVIDENCE-BASED ANSWER. ATYPICAL ANTIPSYCHOTICS ARE EFFECTIVE; so are selective serotonin reuptake inhibitors (SSRIs), and they may be safer. Atypical antipsychotics are an effective short-term (6-12 weeks) treatment for aggressive behavior in patients with Alzheimer’s disease because they consistently decrease aggression scores (strength of recommendation [SOR]: A, multiple randomized ... The cholinesterase inhibitors are the main first-line treatment for Alzheimer’s disease. These drugs attempt to make up for depleted levels of acetylcholine. For moderate to severe disease, doctors often add the NMDA receptor drug. Researchers are still exploring the exact role of the new MAB drug. Aducanumab (Aduhelm) is a MAB and is the ...Apr 24, 2023 · Alzheimer’s disease is a progressive neurodegenerative disorder that affects memory, thinking, behavior, and ultimately, a person’s ability to carry out daily activities. Possible Side Effects. Donepezil (Aricept ®) Yes. All stages of dementia (not recommended in FTD) Nausea, diarrhea, vomiting, upset stomach, lack of hunger, weight loss or low heart rate. Other less common problems are feeling tired, having trouble sleeping, vivid dreams or muscle cramps. Rivastigmine (Exelon ®) Yes. Compare risks and benefits of common medications used for Alzheimer's Disease. Find the most ... Ask the Doctor About Medicine. The FDA hasn't approved any drugs for dementia-related psychosis. Doctors often prescribe atypical, or second-generation antipsychotics meant to help with ...The Food and Drug Administration on Thursday fully approved the Alzheimer’s drug Leqembi, amid concerns about its safety, cost and accessibility. The move marks the first time that a drug meant ...In the early stages of Alzheimer's, the person with dementia may need help remembering to take medications. As a caregiver, you may find it helpful to: Use a pill box organizer. Using a pill box or keeping a daily list or calendar can help ensure medication is taken as prescribed. Develop a routine for giving the medication.Manage medications. Some antidepressant medications, such as bupropion and venlafaxine, can lead to insomnia. Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer's but also can cause insomnia. If the person with dementia is taking these kinds of medications, talk to the doctor.Jun 1, 2018 · Alzheimer disease is the most common form of dementia. In 2016, an estimated 5.2 million Americans age 65 and older had Alzheimer disease. The prevalence is projected to increase to 13.8 million by 2050, including 7 million people age 85 and older. 1. Although no cure for dementia exists, several cognition-enhancing drugs have been approved by ... Sep 27, 2021 · Patients in the study were already taking currently approved medications for Alzheimer's, and this study demonstrates that levetiracetam improves cognitive function better than current treatments ... In the early stages of Alzheimer's, the person with dementia may need help remembering to take medications. As a caregiver, you may find it helpful to: Use a pill box organizer. Using a pill box or keeping a daily list or calendar can help ensure medication is taken as prescribed. Develop a routine for giving the medication. Aug 30, 2023 · While Alzheimer's drugs don't cure the disease, they can improve quality of life and help prolong independence. There are two types of medications approved to treat Alzheimer's: those that can temporarily ease some symptoms, and those that can slow the progression of the disease. Aducanumab (Aduhelm®) has received accelerated approval as a treatment for Alzheimer’s disease from the U.S. Food and Drug Administration (FDA). Aducanumab was the first therapy to demonstrate that removing beta-amyloid, one of the hallmarks of Alzheimer’s disease, from the brain reduces cognitive and functional decline in people living ... Aggressive behaviors may be verbal or physical. They can occur suddenly, with no apparent reason, or result from a frustrating situation. While aggression can be hard to cope with, understanding that the person with Alzheimer's or dementia is not acting this way on purpose can help. Causes. How to respond. Get the full picture of how a drug gets approved for public use in Canada, including a list of the currently approved medications that can treat the symptoms of Alzheimer's. Treatment options. Alzheimer Society of Canada. This downloadable brochure gives an overview of all the treatment options for Alzheimer's that are available to you.Treatment for Alzheimer's disease, the devastating condition that affects more than 5 million Americans, has remained notoriously elusive for decades. Now, a small study released by drug company Eli Lilly offers at least a flicker of hope: It shows that the experimental drug donanemab may significantly slow patients’ cognitive decline.Compare risks and benefits of common medications used for Alzheimer's Disease. Find the most ... Unfortunately, the short answer is no—mood stabilizers have not been found effective for treating dementia, and some may even cause harm. Several different medications—many of which are anticonvulsants (drugs to reduce seizures)—are classified as mood stabilizers. In general, research has not supported widespread use of mood stabilizers ...The Food and Drug Administration on Thursday fully approved the Alzheimer’s drug Leqembi, amid concerns about its safety, cost and accessibility. The move marks the first time that a drug meant ...The late stage of Alzheimer's disease may last from several weeks to several years. As the disease progresses, intensive, around-the-clock care is usually required. What to expect. Bowel and bladder function. Your role as caregiver. Skin and body health. Late-stage care options. Infections and pneumonia. Food and fluids. As a result of FDA’s approval of Aduhelm, patients with Alzheimer’s disease have an important and critical new treatment to help combat this disease. FDA will continue to monitor Aduhelm as it ...The Food and Drug Administration on Thursday fully approved the Alzheimer’s drug Leqembi, amid concerns about its safety, cost and accessibility. The move marks the first time that a drug meant ...5. FDA-approved Alzheimer’s medications Currently, there are 5 FDA-approved drugs that may help delay, lessen, or stabilize Alzheimer’s symptoms like memory loss and confusion. They can improve quality of life both for the person with Alzheimer’s and for the people caring for them.Treatment for Alzheimer's disease, the devastating condition that affects more than 5 million Americans, has remained notoriously elusive for decades. Now, a small study released by drug company Eli Lilly offers at least a flicker of hope: It shows that the experimental drug donanemab may significantly slow patients’ cognitive decline.The Food and Drug Administration on Monday approved Biogen 's Alzheimer's disease drug aducanumab, making it the first medication cleared by U.S. regulators to slow cognitive decline in people ...Jun 7, 2021 · Matt York/AP. The Food and Drug Administration approved the drug aducanumab to treat patients with Alzheimer's disease on Monday. It is the first new drug approved by the agency for Alzheimer's ... Aug 3, 2022 · Treatments for Alzheimer’s Disease. Learn more about initial patient support strategies, the latest approved drugs to slow the disease’s progress, and the status of new clinical trials. Unfortunately, the short answer is no—mood stabilizers have not been found effective for treating dementia, and some may even cause harm. Several different medications—many of which are anticonvulsants (drugs to reduce seizures)—are classified as mood stabilizers. In general, research has not supported widespread use of mood stabilizers ...Aug 19, 2023 · Drugs are the cornerstone of treatment for Alzheimer’s disease. The current medications cannot stop or cure Alzheimer's but may slow the progression of the disease and improve symptoms. Some drugs (like cholinesterase inhibitors) work by improving communication between nerve cells, while others (like antidepressants) may help with behavioral ... It's characterized by changes in the brain that lead to deposits of certain proteins. Alzheimer's disease causes the brain to shrink and brain cells to eventually die. Alzheimer's disease is the most common cause of dementia — a gradual decline in memory, thinking, behavior and social skills. These changes affect a person's ability to function.Jan 12, 2022 · It is weighing the benefits versus the risks associated with Aduhelm and similar Alzheimer’s medications, including headaches, dizziness, falls and brain bleeds, said Dr. Lee Fleisher, CMS ... Treatment for Alzheimer's disease, the devastating condition that affects more than 5 million Americans, has remained notoriously elusive for decades. Now, a small study released by drug company Eli Lilly offers at least a flicker of hope: It shows that the experimental drug donanemab may significantly slow patients’ cognitive decline.These medicines include: Donepezil ( Aricept) Galantamine ( Razadyne, Razadyne ER, Reminyl) Rivastigmine ( Exelon) What to expect: Most people with Alzheimer’s who take one of these medications ... These medicines include: Donepezil ( Aricept) Galantamine ( Razadyne, Razadyne ER, Reminyl) Rivastigmine ( Exelon) What to expect: Most people with Alzheimer’s who take one of these medications ... Get the full picture of how a drug gets approved for public use in Canada, including a list of the currently approved medications that can treat the symptoms of Alzheimer's. Treatment options. Alzheimer Society of Canada. This downloadable brochure gives an overview of all the treatment options for Alzheimer's that are available to you.The late stage of Alzheimer's disease may last from several weeks to several years. As the disease progresses, intensive, around-the-clock care is usually required. What to expect. Bowel and bladder function. Your role as caregiver. Skin and body health. Late-stage care options. Infections and pneumonia. Food and fluids.Evidence Summary. A 2018 meta-analysis examining medications used to alleviate agitation in all types of dementia included 36 RCTs with a total of 5,585 participants (mean age = 81.8 years ± 4.9 ... The cholinesterase inhibitors are the main first-line treatment for Alzheimer’s disease. These drugs attempt to make up for depleted levels of acetylcholine. For moderate to severe disease, doctors often add the NMDA receptor drug. Researchers are still exploring the exact role of the new MAB drug. Aducanumab (Aduhelm) is a MAB and is the ...It's characterized by changes in the brain that lead to deposits of certain proteins. Alzheimer's disease causes the brain to shrink and brain cells to eventually die. Alzheimer's disease is the most common cause of dementia — a gradual decline in memory, thinking, behavior and social skills. These changes affect a person's ability to function.Even though the chief cause of behavioral symptoms is the effect of Alzheimer's disease on the brain, an examination may reveal other treatable conditions that are contributing to the behavior. Contributing conditions may include: Drug side effects. Many people with Alzheimer's take prescription medications for other health issues.These medicines include: Donepezil ( Aricept) Galantamine ( Razadyne, Razadyne ER, Reminyl) Rivastigmine ( Exelon) What to expect: Most people with Alzheimer’s who take one of these medications ... EVIDENCE-BASED ANSWER. ATYPICAL ANTIPSYCHOTICS ARE EFFECTIVE; so are selective serotonin reuptake inhibitors (SSRIs), and they may be safer. Atypical antipsychotics are an effective short-term (6-12 weeks) treatment for aggressive behavior in patients with Alzheimer’s disease because they consistently decrease aggression scores (strength of recommendation [SOR]: A, multiple randomized ...Matt York/AP. The Food and Drug Administration approved the drug aducanumab to treat patients with Alzheimer's disease on Monday. It is the first new drug approved by the agency for Alzheimer's ...Family members often want their loved one to continue on dementia meds. Alzheimer’s advocate Meryl Comer, who cared for her husband with early onset AD at home throughout his illness (see Aug 2014 news story), noted that the drugs seemed to help control his symptoms. “Memantine made him more cooperative, and that made the difference between ... Treatment for Alzheimer's disease, the devastating condition that affects more than 5 million Americans, has remained notoriously elusive for decades. Now, a small study released by drug company Eli Lilly offers at least a flicker of hope: It shows that the experimental drug donanemab may significantly slow patients’ cognitive decline.Ask the Doctor About Medicine. The FDA hasn't approved any drugs for dementia-related psychosis. Doctors often prescribe atypical, or second-generation antipsychotics meant to help with ...Manage medications. Some antidepressant medications, such as bupropion and venlafaxine, can lead to insomnia. Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer's but also can cause insomnia. If the person with dementia is taking these kinds of medications, talk to the doctor.Aducanumab (Aduhelm®) has received accelerated approval as a treatment for Alzheimer’s disease from the U.S. Food and Drug Administration (FDA). Aducanumab was the first therapy to demonstrate that removing beta-amyloid, one of the hallmarks of Alzheimer’s disease, from the brain reduces cognitive and functional decline in people living ... Unfortunately, the short answer is no—mood stabilizers have not been found effective for treating dementia, and some may even cause harm. Several different medications—many of which are anticonvulsants (drugs to reduce seizures)—are classified as mood stabilizers. In general, research has not supported widespread use of mood stabilizers ...

Unfortunately, the short answer is no—mood stabilizers have not been found effective for treating dementia, and some may even cause harm. Several different medications—many of which are anticonvulsants (drugs to reduce seizures)—are classified as mood stabilizers. In general, research has not supported widespread use of mood stabilizers .... Kinney

meds for alzheimer

There are two types of medications approved to treat Alzheimer's: those that can temporarily ease some symptoms, and those that can slow the progression of the disease. Medications don't work for everyone, and they may lose effectiveness over time. They tend to be most effective for people with early to moderate Alzheimer's.Aug 11, 2023 · Common side effects of donepezil may include: nausea, vomiting, diarrhea; loss of appetite; muscle pain; sleep problems ( insomnia ); or. feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Aug 30, 2023 · Infections and immune disorders. Dementia-like symptoms can result from a fever or other side effects of the body's attempt to fight off an infection. Multiple sclerosis and other conditions caused by the body's immune system attacking nerve cells also can cause dementia. Metabolic or endocrine problems. Feb 18, 2022 · However, there is hope for an Alzheimer’s cure breakthrough 2022. Currently, Aducanumab is only approved for use in select patients with mild cognitive impairment or early Alzheimer’s disease. Before the treatment can be administered, all individuals with AD must undergo a PET scan to determine if they have amyloid plaques. Overview of using medications to treat anxiety in Alzheimer's patients. Medications for treating anxiety. Anxiety symptoms are fairly common among patients with Alzheimer's Disease (AD). Such symptoms are likely to make patient care more problematic and, therefore, increase the risk of nursing home placement.Create a calm place for them. Cut out background noise from the TV or radio, clear away clutter, and make their daily tasks as simple as possible. Check for physical reasons they might be agitated ... Create a calm place for them. Cut out background noise from the TV or radio, clear away clutter, and make their daily tasks as simple as possible. Check for physical reasons they might be agitated ...The Food and Drug Administration on Monday approved Biogen 's Alzheimer's disease drug aducanumab, making it the first medication cleared by U.S. regulators to slow cognitive decline in people ...Family members often want their loved one to continue on dementia meds. Alzheimer’s advocate Meryl Comer, who cared for her husband with early onset AD at home throughout his illness (see Aug 2014 news story), noted that the drugs seemed to help control his symptoms. “Memantine made him more cooperative, and that made the difference between ...Get the full picture of how a drug gets approved for public use in Canada, including a list of the currently approved medications that can treat the symptoms of Alzheimer's. Treatment options. Alzheimer Society of Canada. This downloadable brochure gives an overview of all the treatment options for Alzheimer's that are available to you.There are three drugs of this type: donepezil ( Aricept ), galantamine ( Razadyne ), and rivastigmine ( Exelon ). Aricept is the only treatment approved by the FDA for all stages of Alzheimer’s ...For sleep changes due primarily to Alzheimer’s disease, there are non-drug and drug approaches to treatment. Most experts and the National Institutes of Health (NIH) strongly encourage use of non-drug measures rather than medication. Studies have found that sleep medications generally do not improve overall sleep quality for older adults.Evidence Summary. A 2018 meta-analysis examining medications used to alleviate agitation in all types of dementia included 36 RCTs with a total of 5,585 participants (mean age = 81.8 years ± 4.9 ...Even though the chief cause of behavioral symptoms is the effect of Alzheimer's disease on the brain, an examination may reveal other treatable conditions that are contributing to the behavior. Contributing conditions may include: Drug side effects. Many people with Alzheimer's take prescription medications for other health issues. Create a calm place for them. Cut out background noise from the TV or radio, clear away clutter, and make their daily tasks as simple as possible. Check for physical reasons they might be agitated ....

Popular Topics